Tuesday, September 16, 2025

TikTok deal 📱, GPT-5-Codex 🤖, Alzheimer's reversal trial 💊

The US has reached a preliminary deal with China on the fate of TikTok. Both sides have agreed to a framework to divest TikTok from ByteDance ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌  ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ 

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TLDR 2025-09-16

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Big Tech & Startups

U.S. and China Reach 'Framework' for a TikTok Sale (7 minute read)

The US has reached a preliminary deal with China on the fate of TikTok. Both sides have agreed to a framework to divest TikTok from ByteDance. President Trump and Xi Jinping are set to speak on Friday to approve the deal.
OpenAI upgrades Codex with a new version of GPT-5 (2 minute read)

OpenAI's new model, GPT-5-Codex, spends its 'thinking' time more dynamically than previous models. It can spend up to seven hours on a coding task. The model is rolling out now in Codex products to all ChatGPT Plus, Pro, Business, Edu, and Enterprise users. It will be made available to API customers in the future.
🚀

Science & Futuristic Technology

Sam Altman-Backed Retro Biosciences Starts Alzheimer's Reversal Trial (4 minute read)

Retro Biosciences is gearing up for a clinical trial of a drug aimed at reversing the effects of Alzheimer's disease. The drug could potentially restore cognitive function in ways that could redefine longevity treatments. Retro's approach leverages cellular reprogramming techniques. The upcoming trial will test the pill's efficacy in human subjects.
New Ultrasound Helmet Reaches Deep Inside The Brain Without Surgery (4 minute read)

Researchers have created an ultrasound helmet that could offer an alternative to invasive procedures. It can modulate deep-brain circuits without surgery with unrivaled precision. The helmet offers a safe, reversible, and repeatable method for both understanding brain function and developing targeted therapies. It has potential clinical applications for neurological disorders like Parkinson's disease, where deep-brain regions are especially affected.
💻

Programming, Design & Data Science

Reach millions of tech professionals at scale (Sponsor)

Over 6 million tech professionals read TLDR including developers, product managers, marketers, designers and executives. Get in front of your target audience with an ad placement just like this one! Learn more about running a test campaign.
A terminal command that tells you if your USB-C cable is bad (4 minute read)

Android Studio recently added a new feature that warns users when they connect a slow cable to their phones. This post presents a script that checks USB connections in macOS. The script was originally cobbled together with AI, but while it worked, it was a mess to maintain. The developer used AI to port it to Go so the code could be structured more legibly and more easily tweaked.
Apple has a private CSS property to add Liquid Glass effects to web content (3 minute read)

Apple has a custom CSS property named -apple-visual-effect that allows the use of Liquid Glass in iOS 26. It only works by toggling a private setting in WKPreferences, so using it means no App Store approval. No one outside of Apple can use it - and no one knows where Apple is using it.
🎁

Miscellaneous

CubeSats are fascinating learning tools for space (10 minute read)

It's possible to build a space-ready CubeSat using just a few thousand dollars of parts. Many CubeSats use Raspberry Pis and other off-the-shelf components. This post introduces CubeSats and shows readers how they can build their own CubeSats. It also covers several CubeSat projects by other creators.
The Last Days Of Social Media (32 minute read)

Genuine human content is increasingly being sidelined by algorithms. Engineered content and AI slop optimized solely for clicks are being prioritized. Early social media was built for connection. The generative AI-fueled attention economy has broken that illusion. Feeds are no longer crowded with people, but with content.
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Quick Links

Warp Code: build with the coding agent that beats Claude Code and Codex on benchmarks (Sponsor)

Get access to all the best models in one native app - with a built-in code editor, code review panel, MCP tools, and more. Try for $0
Taste (8 minute read)

Taste is humanity's last edge over AI.
Why aren't you a good fit? (5 minute read)

Asking candidates why they shouldn't be hired is a good filter.
StringWa.rs on GPUs: Databases & Bioinformatics 🦠 (16 minute read)

StringZilla is a string library that uses SIMD and SWAR to accelerate string operations on modern CPUs.
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How people actually use ChatGPT vs Claude - and what the differences tell us (8 minute read)

Most ChatGPT usage is not work related, while Claude is used more for automation, especially coding.
The 4p Developer: The Missing Layer in Platform Thinking (13 minute read)

4p developers, the developers that build tools for other developers on platforms, are the fourth party that makes platforms explode.
Programming Deflation (5 minute read)

Understanding, integration, and judgment will be the differentiators that separate signal from noise.

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Thanks for reading,
Dan Ni & Stephen Flanders


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