5-Bullet Friday — Sleeping Pills as Alzheimer’s Prevention, Frisky Dolphin Science, Learning from Zebrafish, and Remembering to Walk

"Above all, do not lose your desire to walk: Every day I walk myself into a state of well-being and walk away from every illness..."  ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­

5-Bullet Friday   The latest from author and investor Tim Ferriss   Hi All!   Here is your weekly dose of 5-Bullet Friday, a list of what I'm pondering and exploring.   This edition is brought to you by ​Coyote the card game​, which I co-created with Exploding Kittens. It just won the Pop Insider "Best Geeky Game" of 2025 and also "Best Stocking Filler" in the MadeForMums Toy Awards 2025 (UK). If you have any kids or relatives aged 10–15, it's a game of thinking fast and laughing faster. Think charades + hot potato + brain fun. Buy it here​ or see the P.S. for more.   What I'm listening to "Stoned on Shiva" (YouTube, Spotify) by Steve Gold.   Podcast episode I'm listening to "Can A Sleeping Pill Help Fight Alzheimer's?" (Apple Podcasts, Spotify, YouTube) by Matt Walker. This is one of many reasons that I'm now experimenting with DORAs for sleep enhancement, given my genetic predisposition to Alzheimer's disease. Be sure to pay attention to the DORA vs. Ambien (zolpidem) comparison. From the episode description: "Matt explores the critical link between sleep and Alzheimer's disease today, explaining how the brain's 'glymphatic system' clears toxic proteins like amyloid and tau during deep sleep. … Matt goes on to discuss groundbreaking research on a new class of sleeping pills, Dual Orexin Receptor Antagonists (DORAs), that may enhance this cleaning mechanism. While preliminary human and animal studies show these drugs can reduce toxic proteins and offer neuroprotection, the findings underscore the profound importance of prioritizing high-quality sleep as a powerful, accessible tool for ensuring long-term brain health."   Research I'm following "The Quest to Reinvent Anesthesia" (UCSF Magazine). If successful, this could reshape healthcare and dramatically reduce costs. Description, bolding mine: "UCSF researchers are scouring millions of compounds – with help from tiny zebrafish – to create anesthetics safe enough to use without an anesthesiologist."   Older research clips that I can't stop forwarding This one is not suitable for work. It was sent to me by a veteran friend who interfaced with military intelligence, and now, I can't stop forwarding them to other friends. So… you're welcome? It's a one-two combo: ​"Dealing with a dolphin's 'urges' - The Girl Who Talked to Dolphins" "Teaching a dolphin to speak English - The Girl Who Talked to Dolphins"   Quote I'm pondering "Above all, do not lose your desire to walk: Every day I walk myself into a state of well-being and walk away from every illness; I have walked myself into my best thoughts, and I know of no thought so burdensome that one cannot walk away from it." ​— Søren Kierkegaard​ (Click here to share on X.) You can complement this edition of 5-Bullet Friday with my recent interview with Roblox co-founder David Baszucki on the ketogenic therapy for brain health, his key business decisions, the Roblox economy, and much, much more. ​ And, as always, please give me feedback on X. Which bullet above is your favorite? What do you want more or less of? Other suggestions? Please let me know. Just send a tweet to @tferriss and put #5BulletFriday at the end so I can find it. ​ Have a wonderful weekend, all. ​ Much love to you and yours, ​ Tim ​ P.S. Need a little break from the serious stuff? Coyote is an award-winning card game that's hot potato + charades + a test of wits. Just keep the beat and sabotage your friends to win! Buy it here​. - EASY TO LEARN - Learn in minutes and jump right in. Coyote turns even the quietest person into a performer and the most competitive player into a giggling mess. ​ - FAMILY-FRIENDLY - Perfect for families with kids aged 10–15 or adults who are kids at heart. 3–8 players. ​- MORE THAN HILARIOUS - Coyote is silly family fun that makes you think. ​- POCKET-SIZED - Play anywhere! This deck of 66 cards is the perfect stocking stuffer for kids, nieces, nephews, and anyone who likes pocket-sized fun. ​- INFINITE REPLAYABILITY - Every game is different; no two games are the same. Play competitively or cooperatively and escalate the action with "coyote" cards until you're the last person standing… or you win or lose as a team. ​- MAKE IT YOUR OWN - There are blank cards, so you can create your own "family rules" with laugh-out-loud additions. This customizability makes Coyote a family favorite. Forwarded this message? Sign up here. Join millions of monthly readers. Get exclusive content, private Q&As, giveaways, and more. No spam, ever. Just great stuff.   Sign Up   Listen to The Tim Ferriss Show Podcast The Tim Ferriss Show is one of the most popular podcasts in the world with more than one billion downloads. It has been selected for "Best of Apple Podcasts" three times, it is often the #1 interview podcast across all of Apple Podcasts, and it's been ranked #1 out of 400,000+ podcasts  on many occasions.     Podcasts   Apple Podcasts   Overcast   Spotify   Tim's Blog Read Tim's Books     Amazon   Audible  B & N   Tim's Blog Follow Tim: DO NOT REPLY HERE: Due to volume, please do not reply to this email. Sadly we are unable to read 1000+ email replies daily. To reply to Tim, please do so in the blog comments here.   No longer want these emails?  Unsubscribe 3​11​2 Win​dso​r R​d., Box #UNS, Austin TX 78703, United States   ​