OpenAI's GPT-OSS 🤖, Ozempic anti-aging 👴, hardware has changed 💻

OpenAI 120B open model achieves near-party with OpenAI o4-mini on core reasoning benchmarks while running efficiently on a single 80 GB GPU ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌  ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ 

Sign Up |Advertise|View Online TLDR Together With TLDR 2025-08-06  🚀 Faster mobile releases with automated QA (Sponsor) Manual testing on mobile devices is too slow and too limited. It forces teams to cut releases a week early just to test before submitting them to app stores. And without broad device coverage, issues slip through. QA Wolf's AI-native service delivers 80% automated test coverage in weeks, with tests running on real iOS devices and Android emulators—all in 100% parallel with zero flakes. QA cycles reduced to just 15 minutes Multi-device + gesture interactions fully supported Reliable test execution with zero flakes Human-verified bug reports No more manual E2E testing. No more slow QA cycles. No more bugs reaching production. ⭐️ Rated 4.8/5 on G2 Schedule a demo to learn more 📱 Big Tech & Startups Anthropic Unveils More Powerful AI Model Ahead of Rival GPT-5 Release (2 minute read) Anthropic's new model, Opus 4.1, is more capable at coding, research, and data analysis and better at fielding complex multistep problems than previous versions. It can better navigate large codebases and make more precise modifications to code. Opus 4.1 scores two percentage points higher than its predecessor on SWE-Bench Verified, a popular coding evaluation benchmark. Anthropic is currently finalizing a deal to raise as much as $5 billion in a new funding round at a valuation of $170 billion. OpenAI's new open weight (Apache 2) models are really good (15 minute read) OpenAI's long-awaited open weight models have been released. The 120B model achieves near-party with OpenAI o4-mini on core reasoning benchmarks while running efficiently on a single 80 GB GPU. The 20B model delivers similar results to OpenAI o3-mini on common benchmarks and can run on edge devices with just 16 GB of memory. Both models are mixture-of-experts. It is likely that OpenAI now offers the best available open weights models. 🚀 Science & Futuristic Technology Ozempic Shows Anti-Aging Effects in First Clinical Trial, Reversing Biological Age by 3.1 Years (3 minute read) Ozempic demonstrated remarkable anti-agent effects in a randomized controlled trial involving 108 people with HIV-associated lipohypertrophy, a condition characterized by excess fat accumulation and accelerated cellular aging. The researchers used epigenetic clocks to assess biological aging and found that those on semaglutide became 3.1 years biologically younger on average by the end of the study. The anti-aging effects weren't uniform across all body systems - the most dramatic improvements occurred in the inflammatory system and brain. The researchers believe that the anti-aging properties of semaglutide stem from its effects on fat distribution and metabolic health. First Evidence of Microplastic Mobilization in a Human Subject – A Self-Experiment (17 minute read) Microplastics are everywhere. Studies show that microplastic burden strongly correlates with negative health outcomes. This post presents an experimental protocol that tricks cells into releasing microplastics back into the blood, where they can be transported to the liver for biliary excretion or actively removed with plasma exchange. It involves using a compound derived from broccoli as a microplastics mobilizer. 💻 Programming, Design & Data Science Meet the AI-Powered App that's helped users lose millions of lbs (Sponsor) Over 18 million people have turned to Simple—a science-backed app that combines intermittent fasting with AI coaching (Avo™) to support sustainable weight loss, no restrictive diets required. Designed for busy techies who prefer data-driven solutions over calorie counting. 🔥TLDR readers get 50% off → Take the quiz here. stagewise (GitHub Repo) stagewise is a frontend coding agent for production codebases. Developers just have to tell the agent what they want to change, click on elements to let the agent know where a change should happen, and then stagewise does the rest. stagewise can be customized with plugins, and it is compatible with all kinds of frameworks. It features a dedicated frontend agent, but developers can use any other compatible agent through stagewise's open agent interface. Adopting Claude Code: Riding the Software Economics Singularity (12 minute read) Programming is quickly changing. Claude Code fundamentally changed what is possible when working at scale. AI has removed a lot of friction in the development process, allowing tasks that weren't worth tackling before to be completed. However, when coding speed stops being the limiting factor, new bottlenecks emerge. The constraint now isn't how fast features can be implemented, it's how quickly decisions can be made about what to build. 🎁 Miscellaneous DeepMind reveals Genie 3 "world model" that creates real-time interactive simulations (6 minute read) Google DeepMind's Genie 3 model can create interactive worlds from prompts or images. It can create continuously generated environments that can be changed on the fly. The ability to create alterable 3D environments could make games more dynamic for players and offer developers new ways to prove out concepts and level designs. Examples of environments generated by the model are available in the article. Ignore Previous Directions 5: hardware has changed (6 minute read) Writing code that runs efficiently is hard. Hardware has improved significantly in the past few years. GenAI has accelerated this hardware transformation. The software side has a lot of work to do to catch up with the reality of the hardware. ⚡ Quick Links Craving more AI in your inbox? (Sponsor) TLDR AI is your daily fix of LLMs, GenAI, and deep learning goodness. Same TLDR format. Still free. Subscribe now. Developers, Reinvented (11 minute read) The role of the software developer is set to significantly change to one of managing agents to achieve outcomes. Apple's latest Liquid Glass design shows it won't back down with iOS 26 (4 minute read) Despite criticism, Apple isn't backing down from its original Liquid Glass vision, with the look being expanded to even more UI elements in iOS 26 beta 5. Coinbase Debuts 'Embedded' Crypto Wallet for Developers—With Stablecoin Focus (2 minute read) Coinbase's Embedded Wallets product allows users to access crypto wallets with just an email address or phone number. Are "No Results" product searches holding your business back? Make your site search best-in-class with Algolia (Sponsor) Algolia AI search understands every user at every journey stage, connecting your customers to the products they want, when they want them. Find out more and sign up for free (no credit card required) What we learned from creating PostCSS (15 minute read) PostCSS is a CSS automation tool used by Google, Wikipedia, Tailwind, and 38% of developers. No, AI is not Making Engineers 10x as Productive (21 minute read) Any software engineer who has worked on actual code in an actual company knows that it isn't possible to compress the back and forth of 3 months of code review into one and a half weeks. When to Hire a Computer Performance Engineering Team (26 minute read) Hiring good performance engineers isn't easy because it's a specialized area with a limited talent pool. Love TLDR? Tell your friends and get rewards! Share your referral link below with friends to get free TLDR swag! https://refer.tldr.tech/7c97ce4b/ Track your referrals here. Want to advertise in TLDR? 📰 If your company is interested in reaching an audience of tech executives, decision-makers and engineers, you may want to advertise with us. Want to work at TLDR? 💼 Apply here or send a friend's resume to jobs@tldr.tech and get $1k if we hire them! If you have any comments or feedback, just respond to this email! Thanks for reading, Dan Ni & Stephen Flanders Manage your subscriptions to our other newsletters on tech, startups, and programming. Or if TLDR isn't for you, please unsubscribe.